◀ Back to PTGS2

NTN1 — PTGS2

Text-mined interactions from Literome

Ranganathan et al., American journal of physiology. Renal physiology 2013 (Inflammation...) : Overexpression of netrin-1 in spleen and kidney of transgenic mice increased expression of arginase-1, IL-4, and IL-13 and decreased expression of COX-2 , indicating a phenotypic switch in macrophage polarization toward an M2-like phenotype
Ranganathan et al., Kidney Int 2013 : Consistent with in vivo data, both LPS- and IFN? induced inflammatory cytokine production in macrophages and IL-17 induced IFN? production in neutrophils were suppressed by netrin-1 in vitro by suppression of COX-2 expression ... Moreover, netrin-1 regulates COX-2 expression at the transcriptional level through the regulation of NF?B activation ... Moreover, netrin-1 regulates COX-2 expression at the transcriptional level through the regulation of NF?B activation