Gene interactions and pathways from curated databases and text-mining

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IL8 — MKNK1

Text-mined interactions from Literome

Cherla et al., J Leukoc Biol 2006 (MAP Kinase Signaling System) : The MAPK inhibitors or Mnk1 inhibitor blocked soluble interleukin (IL)-1beta and IL-8 production or release by 73-96 %
Fukunaga et al., EMBO J 1997 : Further, MNK1 was activated upon stimulation of HeLa cells with 12-O-tetradecanoylphorbol-13-acetate, fetal calf serum, anisomycin, UV irradiation, tumor necrosis factor-alpha, interleukin-1beta , or osmotic shock, and the activation by these stimuli was differentially inhibited by the MEK inhibitor PD098059 or the p38 MAP kinase inhibitor SB202190