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CSF2 — TLR4
Text-mined interactions from Literome
Bozinovski et al., Am J Physiol Lung Cell Mol Physiol 2004
(Pneumonia) :
Here we report for the first time that the physiological expression of
Toll-like receptor-4 in lung is
reduced by
anti-GM-CSF
Krutzik et al., Nat Med 2005
(Leprosy) :
CD1b+ dendritic cells were expanded by
TLR mediated upregulation of granulocyte-macrophage
colony stimulating factor ( GM-CSF ) and its receptor, promoted T cell activation and secreted proinflammatory cytokines
Berclaz et al., Am J Respir Cell Mol Biol 2007
:
Because granulocyte macrophage colony stimulating factor ( GM-CSF ) -deficient ( GM ( -/- ) ) mice are hyporesponsive to LPS, we evaluated the
role of
GM-CSF in
TLR-4 signaling in AMs
O'Mahony et al., International journal of medical sciences 2008
:
Of the cytokines examined, IFN-gamma and
GM-CSF caused the greatest effects on
TLR expression ...
GM-CSF up-regulated expression of TLR2 and
TLR4 in neutrophils and TLR2 in monocytes
Brosbøl-Ravnborg et al., Clin Exp Immunol 2009
(Crohn Disease) :
In CD patients,
TLR induced
GM-CSF secretion was impaired by both NOD2 dependent and -independent mechanisms
Hammad et al., Nat Med 2009
(Asthma...) :
TLR4 triggering on structural cells
caused production of the innate proallergic cytokines thymic stromal lymphopoietin, granulocyte-macrophage
colony stimulating factor , interleukin-25 and interleukin-33
Fukuzono et al., Arch Biochem Biophys 2010
:
G-CSF and
GM-CSF did not
affect TLR agonist induced phosphorylation of ERK, p38, JNK, Akt, and IkappaBalpha ... These findings suggest that G-CSF and
GM-CSF exert the opposite effects on TLR agonist induced cytokine production, and G-CSF negatively
regulates TLR agonist induced cytokine production in neutrophils via activation of STAT3
Standiford et al., Am J Physiol Lung Cell Mol Physiol 2012
(Acute Lung Injury...) :
TLR4 dependent
GM-CSF protects against lung injury in Gram negative bacterial pneumonia
Parajuli et al., Journal of neuroinflammation 2012
:
GM-CSF enhanced
TLR4 and CD14 expressions in microglia and subsequent LPS binding to the cell surface ... GM-CSF upregulated the levels of p-ERK1/2 and p-p38, suggesting that
induction of
TLR4 and CD14 expression by
GM-CSF was mediated through ERK1/2 and p38, respectively ... These results suggest that
GM-CSF upregulates
TLR4 and CD14 expression in microglia through ERK1/2 and p38, respectively, and thus promotes the LPS receptor mediated inflammation in the CNS