◀ Back to TLR4
AKT2 — TLR4
Text-mined interactions from Literome
Li et al., Infect Immun 2003
:
Further, these studies suggest that PI3-kinase is an important mediator of LPS and IL-1 beta signaling leading to NF-kappa B activation in endothelial cells and that
Akt is
necessary but not sufficient for NF-kappa B activation by
TLR4
Miller et al., Arterioscler Thromb Vasc Biol 2005
(Atherosclerosis) :
In turn,
TLR4 regulated phosphorylation of ERK1/2 but not of
Akt , suggesting that mmLDL induced PI3K activation is TLR4 independent
Lentschat et al., J Immunol 2005
:
In addition to inhibition of TLR4 mediated MAPK phosphorylation in macrophages, mastoparan blunted IL-1R associated kinase-1 kinase activity induced by LPS, but not by TLR2 agonists, yet failed to affect phosphorylation of
Akt by phosphoinositol-3-kinase
induced by either TLR2- or
TLR4 mediated signaling
Ha et al., Cardiovasc Res 2005
(Cardiomegaly...) :
Our results demonstrate that
TLR4 is a novel receptor contributing to the development of cardiac hypertrophy in vivo and that both the TLR4 mediated pathway and
PI3K/Akt/mTOR signaling are
involved in the development of cardiac hypertrophy in vivo
Zhang et al., J Neuroimmunol 2008
(Disease Models, Animal) :
Here, we demonstrate an essential role for the
TLR4 mediated phosphoinositide 3-kinase
(PI3K)/Akt signaling ... Therefore, stress modulates the immune system through
TLR4 mediated
PI3K/Akt signaling
Santos-Sierra et al., EMBO J 2009
:
In contrast to TLR2/6,
TLR2/1 does not
require Mal or MyD88 for
Akt phosphorylation
Doan et al., Anticancer Res 2009
(Colorectal Neoplasms) :
Toll-like receptor 4 activation
increases Akt phosphorylation in colon cancer cells
Fan et al., EMBO J 2010
:
While FoxO1 potentiates
Tlr4 signalling, activation of the latter
induces AKT and subsequently inactivates FoxO1, establishing a self limiting mechanism of inflammation
Kim et al., Am J Chin Med 2010
(Inflammation...) :
We examined the effect of hirsutenoxime on the
Toll-like receptor 4-mediated activation of
Akt and nuclear factor ( NF ) -?B in lipopolysaccharide stimulated keratinocytes ... Hirsutenoxime, a cell signaling Akt inhibitor, and Bay 11-7085, an inhibitor of NF-?B activation, attenuated the lipopolysaccharide induced expression of
Toll-like receptor 4 ,
activation of NF-?B and
Akt , and the production of chemokines and reactive oxygen/nitrogen species
Hsu et al., Cancer Res 2011
(Colorectal Neoplasms...) :
Taken together, the results indicate that stimulation of the
TLR4/MD2 complex by LPS
activates PI3K/AKT signaling and promotes downstream ß1 integrin function, thereby increasing the adhesiveness and metastatic capacity of CRC cells
Yang et al., Mol Biol Rep 2012
(Coronary Restenosis...) :
High mobility group box-1 induces migration of vascular smooth muscle cells via
TLR4 dependent
PI3K/Akt pathway activation
Bauerfeld et al., J Immunol 2012
:
TLR4 mediated
AKT activation is MyD88/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages
Xia et al., J Pineal Res 2012
(Inflammation) :
In addition, melatonin inhibited
TLR4 mediated
Akt phosphorylation in LPS stimulated macrophages
Zhang et al., Cell Biol Toxicol 2012
(Prostatic Neoplasms) :
TLR4 ligation
resulted in a marked increase in the phosphorylation of phosphatidylinositol 3-kinase (PI3-K) and
Akt