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PDK1 — SLC2A4
Text-mined interactions from Literome
Bandyopadhyay et al., Mol Endocrinol 1999
:
Overexpression of wild-type
PDK-1 provoked increases in the activity of cotransfected hemagglutinin ( HA ) -tagged PKC-zeta and concomitantly
enhanced HA-tagged
GLUT4 translocation ... Expression of both kinase-inactive
PDK-1 and an activation-resistant form of PKC-zeta that is mutated at Thr-410, the immediate target of PDK-1 in the activation loop of PKC-zeta,
inhibited insulin induced increases in both HA-PKC-zeta activity and
HA-GLUT4 translocation to the same extent as kinase-inactive PKC-zeta ... In contrast to the T410A PKC-zeta mutant, an analogous double mutant of PKB ( T308A/S473A ) that is resistant to PDK-1 activation had only a small effect on insulin stimulated HA-GLUT4 translocation and did not inhibit
HA-GLUT4 translocation
induced by overexpression of wild-type
PDK-1
Grillo et al., FEBS Lett 1999
:
We demonstrated that the overexpression of
PDK1 ( 3-phosphoinositide dependent protein kinase 1 ), a downstream effector of PI 3-kinase,
stimulated Glut 4 translocation in adipocytes