Schachtrup et al., Proc Natl Acad Sci U S A 2007
:
Inhibition of Src family kinases that mediate the cross-talk between integrin and growth factor receptors rescue the fibrinogen induced phosphorylation of EGFR ... These results identify fibrinogen as the first blood derived inhibitor of neurite outgrowth and suggest fibrinogen induced EGFR transactivation on neuronal cells as a molecular link between vascular and neuronal damage in the CNS after injury
Ryu et al., Journal of thrombosis and haemostasis : JTH 2009
(Neurodegenerative Diseases) :
In microglia, fibrinogen mediates activation of Akt and Rho via the CD11b/CD18 integrin receptor, while in neurons fibrinogen induces phosphorylation of epidermal growth factor (EGF) receptor via the alphavbeta3 integrin