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APP — HRD

Text-mined interactions from Literome

Kaneko et al., J Neurosci 2010 (Alzheimer Disease) : HRD1 promoted APP ubiquitination and degradation, resulting in decreased generation of Abeta ... Immunohistochemical analysis revealed that suppression of HRD1 expression inhibited APP aggresome formation, resulting in apoptosis
Kaneko et al., J Pharmacol Sci 2012 (Alzheimer Disease) : We cloned the novel ubiquitin ligase HRD1, which is involved in ERAD, and showed that HRD1 promoted amyloid precursor protein (APP) ubiquitination and degradation, resulting in decreased generation of amyloid ß ( Aß ) ... In addition, suppression of HRD1 expression caused APP accumulation and promoted Aß generation associated with ER stress and apoptosis