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CASP1 — TYR

Text-mined interactions from Literome

Kim et al., Toxicology 2000 : Both Asp-Glu-Val-Asp-aldehyde ( DEVD-cho ) and Tyr-Val-Ala-Asp-chloromethylketone ( YVAD-cmk ), selective inhibitors of caspase-3 and caspase-1, respectively, suppressed significantly cadmium induced cell death
Corasaniti et al., Br J Pharmacol 2001 (Neuroblastoma) : 4. Death of CHP100 cells induced by gp120 is also prevented by acetyl-Tyr-Val-Ala-Asp-chloromethylketone ( Ac-YVAD-CMK ; 10-100 microM ), a second inhibitor of ICE , supporting the concept that the viral protein stimulates the conversion of the 31 kDa pro-IL-1beta in to the 17 kDa mature cytokine which is then secreted to cause death
Tatsuta et al., J Immunol 1996 (Burkitt Lymphoma...) : Acetyl-Tyr-Val-Ala-Asp-chloromethylketone , a tetrapeptidyl inhibitor of ICE , prevented Fas mediated apoptosis strongly in SKW6.4 and H-9 cells but weakly or marginally in other cells
McAlindon et al., Gut 1998 (Colitis, Ulcerative...) : Ac-Tyr-Val-Ala-Asp-CHO , a specific peptide aldehyde inhibitor of ICE , significantly reduced the amount of mature IL-1 beta released by isolated IBD macrophages ( from a median of 1.2 ( range 0.78-4.42 ) ng/ml to 0.43 ( 0.21-1.6 ) ng/ml ; p < 0.01 )
Desrosiers et al., Biochem Cell Biol 1998 : The only protease inhibitor protecting Cdc42 but not RhoA from proteolytic degradation in brush border membranes was the synthetic peptide acetyl-Tyr-Val-Ala-Asp-aldehyde , a selective inhibitor of interleukin-1 beta converting enzyme
Guo et al., Exp Cell Res 1998 : Both Acetyl-Tyr-Val-Ala-Asp-chloromethylketone and Acetyl-Tyr-Val-Ala-Asp-aldehyde, selective caspase-1 ( interleukin-1beta converting enzyme ) inhibitors , exerted only partial protection of cells from apoptosis at higher concentrations