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IL8 — MAP3K7

Text-mined interactions from Literome

Holtmann et al., J Biol Chem 2001 : Expression of the MAP kinase kinase kinase ( MAPKKK ) TAK1 together with its coactivator TAB1 in HeLa cells activated all three pathways and was sufficient to induce IL-8 formation, NF-kappaB + JNK2 mediated transcription from a minimal IL-8 promoter, and p38 MAPK mediated stabilization of a reporter mRNA containing IL-8 derived regulatory mRNA sequences
Frobøse et al., Mol Endocrinol 2006 : Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex
Kettner-Buhrow et al., Biochem Biophys Res Commun 2006 (MAP Kinase Signaling System) : dsiRNA against TAK1 or TAB1 significantly suppressed their target proteins as well as TAK1 mediated activation of NFkappaB, p38 MAPK, and JNK, and of IL-8 transcription
Thiefes et al., EMBO Rep 2006 : YopP, but not the catalytically inactive mutant YopP ( C172A ), also suppresses basal and interleukin-1-inducible activation of endogenous TAK1 , TAB1 and TAB2
da Silva Correia et al., Cell Death Differ 2007 (Breast Neoplasms) : In contrast, several lines of evidence show that Nod1 dependent JNK activation and IL-8 production did not require the presence of caspase 8 but required activation of TAK1 as well as RIP2
Zhou et al., World J Gastroenterol 2008 (Adenocarcinoma...) : Viable LBG or LBG- ( s ) pretreatment attenuated the expression of TLR4, inhibited the phosphorylation of TAK1 and p38MAPK, prevented the activation of NF-kappaB, and consequently blocked IL-8 production
Inagaki et al., J Biol Chem 2008 : Tumor necrosis factor- and interleukin-1 induced activation of TAK1 was entirely normal in Tab1-deficient MEFs and could activate both mitogen activated protein kinases and NF-kappaB
Kim et al., PloS one 2009 (Colitis) : Finally, we showed that TAK1 is essential for interleukin 1- and bacterial components induced expression of cytoprotective factors such as interleukin 6 and cycloxygenase 2
Pera et al., Am J Physiol Lung Cell Mol Physiol 2012 (MAP Kinase Signaling System) : Role for TAK1 in cigarette smoke induced proinflammatory signaling and IL-8 release by human airway smooth muscle cells ... The role of TAK1 in CS-induced IL-8 release is not known ... The aim of this study was to investigate the role of TAK1 in CS-induced NF-?B and MAP kinase signaling and IL-8 release by human ASM cells ... In addition, inhibitors of TAK1 and the NF-?B ( SC-514 ; 50 µM ) and ERK-1/2 ( U-0126 ; 3 µM ) signaling inhibited the CSE induced IL-8 release by ASM cells ... These data indicate that TAK1 plays a major role in CSE induced ERK-1/2 and NF-?B signaling and in IL-8 release by human ASM cells