Gene interactions and pathways from curated databases and text-mining

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CD40LG — IL8

Text-mined interactions from Literome

von Leoprechting et al., Cancer Res 1999 (Melanoma) : CD40 ligation on MM by CD40L transfected murine L-cells or by a soluble CD40L fusion protein up-regulated their expression of intercellular adhesion molecule-1 and MHC class I and class II molecules and their secretion of IL-6, IL-8 , tumor necrosis factor-a, and granulocyte macrophage colony stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappaB
Sugiura et al., J Immunol 2000 (Dermatomyositis...) : Increased CD40 expression on muscle cells of polymyositis and dermatomyositis : role of CD40-CD40 ligand interaction in IL-6, IL-8 , IL-15, and monocyte chemoattractant protein-1 production ... Recombinant human CD40L markedly increased the production of IL-6, IL-8 , IL-15, and monocyte chemoattractant protein-1 of SkMC 2859
McDowell et al., Infect Immun 2002 : Leishmania priming of human dendritic cells for CD40 ligand induced interleukin-12p70 secretion is strain and species dependent
Möttönen et al., Arthritis Res 2002 (Arthritis, Rheumatoid) : Regulation of CD154 induced interleukin-12 production in synovial fluid macrophages
Wagner et al., Arterioscler Thromb Vasc Biol 2002 : One consequence of this statin dependent downregulation of CD40 expression was a decrease in CD40 ligand induced endothelial interleukin-12 expression
Loskog et al., Clin Cancer Res 2005 (Carcinoma...) : CD40L stimulation of dendritic cells induces interleukin-12 expression that drives Th1 type of immune responses with activation of cytotoxic T cells
Zirlik et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis...) : TRAF-3 silencing in ECs showed increased CD40L induced IL-6, MCP-1, and IL-8 expression, whereas TRAF-6 silencing increased selectively CD40L induced MCP-1 expression
Bose et al., Hum Immunol 2007 (Carcinoma, Squamous Cell...) : Natural killer cell mediated cytotoxicity of tumor cells initiated by neem leaf preparation is associated with CD40-CD40L mediated endogenous production of interleukin-12
Li et al., American journal of physiology. Renal physiology 2009 (MAP Kinase Signaling System) : CD154/CD40 mediated ICAM-1 upregulation was not affected by preincubation of monolayers with the CXCR-1 blocking antibody, indicating that ICAM-1 expression occurs independent of CD154 mediated IL-8 production ... This cascade of events is independent of CD40/CD154 mediated IL-8 stimulation and ICAM-1 production and serves to amplify the inflammatory response
Maurais et al., Virology 2009 (HIV Infections) : Human immunodeficiency virus type 1-anchored CD40 ligand induces secretion of the chemokine interleukin-8 by human primary macrophages ... Importantly, we show that wild-type CD40L remains functional since CD40L bearing virions mediate NF-kappaB activation in a CD40 expressing reporter cell line and induce secretion of the chemokine IL-8 by monocyte derived macrophages
Missiou et al., Thromb Haemost 2010 (Cardiovascular Diseases...) : Stimulation with recombinant CD40L or membranes over expressing CD40L induced a time- and dose dependent expression of IL-6, MCP-1, IL-8 , and PAI-1
Kennedy et al., Eur J Immunol 1996 : CD40/CD40 ligand interactions are required for T cell dependent production of interleukin-12 by mouse macrophages