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CD40LG — IL8
Text-mined interactions from Literome
von Leoprechting et al., Cancer Res 1999
(Melanoma) :
CD40 ligation on MM by CD40L transfected murine L-cells or by a soluble
CD40L fusion protein
up-regulated their expression of intercellular adhesion molecule-1 and MHC class I and class II molecules and their secretion of IL-6,
IL-8 , tumor necrosis factor-a, and granulocyte macrophage colony stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappaB
Sugiura et al., J Immunol 2000
(Dermatomyositis...) :
Increased CD40 expression on muscle cells of polymyositis and dermatomyositis :
role of
CD40-CD40 ligand interaction in IL-6,
IL-8 , IL-15, and monocyte chemoattractant protein-1 production ... Recombinant human
CD40L markedly
increased the production of IL-6,
IL-8 , IL-15, and monocyte chemoattractant protein-1 of SkMC 2859
McDowell et al., Infect Immun 2002
:
Leishmania priming of human dendritic cells for
CD40 ligand induced
interleukin-12p70 secretion is strain and species dependent
Möttönen et al., Arthritis Res 2002
(Arthritis, Rheumatoid) :
Regulation of
CD154 induced
interleukin-12 production in synovial fluid macrophages
Wagner et al., Arterioscler Thromb Vasc Biol 2002
:
One consequence of this statin dependent downregulation of CD40 expression was a decrease in
CD40 ligand induced endothelial
interleukin-12 expression
Loskog et al., Clin Cancer Res 2005
(Carcinoma...) :
CD40L stimulation of dendritic cells
induces interleukin-12 expression that drives Th1 type of immune responses with activation of cytotoxic T cells
Zirlik et al., Arterioscler Thromb Vasc Biol 2007
(Atherosclerosis...) :
TRAF-3 silencing in ECs showed increased
CD40L induced IL-6, MCP-1, and
IL-8 expression, whereas TRAF-6 silencing increased selectively CD40L induced MCP-1 expression
Bose et al., Hum Immunol 2007
(Carcinoma, Squamous Cell...) :
Natural killer cell mediated cytotoxicity of tumor cells initiated by neem leaf preparation is associated with
CD40-CD40L mediated endogenous production of
interleukin-12
Li et al., American journal of physiology. Renal physiology 2009
(MAP Kinase Signaling System) :
CD154/CD40 mediated ICAM-1 upregulation was not affected by preincubation of monolayers with the CXCR-1 blocking antibody, indicating that ICAM-1 expression occurs independent of
CD154 mediated
IL-8 production ... This cascade of events is independent of
CD40/CD154 mediated
IL-8 stimulation and ICAM-1 production and serves to amplify the inflammatory response
Maurais et al., Virology 2009
(HIV Infections) :
Human immunodeficiency virus type 1-anchored
CD40 ligand induces secretion of the chemokine
interleukin-8 by human primary macrophages ... Importantly, we show that wild-type
CD40L remains functional since CD40L bearing virions mediate NF-kappaB activation in a CD40 expressing reporter cell line and
induce secretion of the chemokine
IL-8 by monocyte derived macrophages
Missiou et al., Thromb Haemost 2010
(Cardiovascular Diseases...) :
Stimulation with recombinant
CD40L or membranes over expressing CD40L
induced a time- and dose dependent expression of IL-6, MCP-1,
IL-8 , and PAI-1
Kennedy et al., Eur J Immunol 1996
:
CD40/CD40 ligand interactions are
required for T cell dependent production of
interleukin-12 by mouse macrophages