Gene interactions and pathways from curated databases and text-mining

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EGF — ITGB1

Text-mined interactions from Literome

Smida Rezgui et al., Int J Cancer 2000 (Calcium Signaling...) : Our results provide evidence that EGF induced up-regulation of alpha 2 beta 1 integrin contributes to the enhancement of cell-cell adhesion, leading to cell aggregate formation, which permits the escape of A431 cells to EGF induced death by alpha 2 beta 1 integrin signaling
Lee et al., Biochim Biophys Acta 2002 : The alpha5beta1 integrin selectively enhances epidermal growth factor signaling to the phosphatidylinositol-3-kinase/Akt pathway in intestinal epithelial cells
Yamanaka et al., Exp Cell Res 2003 (Adenocarcinoma...) : The results of an immunoprecipitation study showed that EGF up-regulated the expression of alpha2beta1-integrin in a dose dependent manner ... The results suggest that EGF promotes cell motility and migration and increases the expression of alpha2beta1-integrin , possibly by decreasing FAK phosphorylation
Duncan et al., J Biol Chem 2006 : Furthermore, MSK1/2 control EGF induced IkappaB alpha promoter H3-Ser10 phosphorylation in the absence of elevated transcription
Wang et al., Cell Signal 2008 (Breast Neoplasms...) : EGF induced integrin beta1 phosphorylation was dampened, consistent with defects in adhesion
Zhang et al., Int J Cancer 2009 (Brain Neoplasms...) : Furthermore, epidermal growth factor induced ACAP1 phosphorylation and integrin beta1 phosphorylation were also blocked, consistent with defects in adhesion
Krensel et al., Int J Cancer 1999 (Adenocarcinoma...) : The EGF induced up-regulation of the alpha2beta1 integrin was instrumental in increasing collagen adhesion of A549 but only partly in the case of A431 cells, in which cells the alpha2beta1 integrin may have additional functions besides serving as cell-ECM receptor