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CDKN1A — EGF

Text-mined interactions from Literome

Thomas et al., J Cell Physiol 1999 (Breast Neoplasms) : Furthermore, putrescine reversal of EGF effects was associated with the down-regulation of EGF induced p21
Kawamata et al., Int J Oncol 1999 (Urinary Bladder Neoplasms) : Reportedly EGF activates STAT, induces the expression of p21waf1 , and subsequently inhibits the growth of several types of cancer cells ... EGF enhanced the expression of p21waf1 mRNA in T24, 1T-2, 1T-3 and A431, and activated the p21waf1 promoter in T24 cells
Ichiba et al., J Gastroenterol 2002 (Esophageal Neoplasms) : The introduction of a dominant negative STAT1 construct into TE8 cells abolished not only growth inhibition but also p21/WAF1 induction by EGF
Giles et al., J Biol Chem 2003 (Breast Neoplasms) : Over- and underexpression of HuR in MDA-468 cells did not affect EGF induced p21 ( WAF1 ) protein expression or growth inhibition ... We conclude that EGF induced p21 ( WAF1 ) protein expression is mediated largely by stabilization of p21 ( WAF1 ) mRNA elicited via multiple 3'-UTR cis-elements
Wang et al., Eur J Nucl Med Mol Imaging 2003 (Breast Neoplasms) : Antisense imaging of epidermal growth factor induced p21 ( WAF-1/CIP-1 ) gene expression in MDA-MB-468 human breast cancer xenografts ... A concentration dependent inhibition of EGF induced p21 ( WAF-1/CIP-1 ) protein expression was achieved in MDA-MB-468 cells by treatment with antisense ODNs with up to a tenfold decrease observed at 1 microM ... Successful imaging of EGF induced p21 ( WAF-1/CIP-1 ) gene expression in MDA-MB-468 xenografts was achieved at 48 h post injection of ( 111 ) In-labeled antisense ODNs ( 3.7 MBq ; 2 microg ) ... Biodistribution studies showed a significantly higher tumor accumulation of ( 111 ) In-labeled antisense ODNs in the presence of EGF induction of the p21 ( WAF-1/CIP-1 ) gene ( 0.32 % +/-0.06 % injected dose/g ) compared with normal saline treated control mice ( 0.11 % +/-0.07 % injected dose/g ) ... The tumor/blood ratio for antisense ODNs in the presence of EGF induction of the p21 ( WAF-1/CIP-1 ) gene ( 4.87+/-0.87 ) was also significantly higher than for control random sequence ODNs ( 2.14+/-0.69 ) or for mice receiving antisense ODNs but not treated with EGF ( 2.07+/-0.37 )
Akca et al., Growth Factors 2003 (Uterine Cervical Neoplasms) : An inhibitor of PKC, GF 109203X inhibited EGF mediated suppression of TNF-alpha induced accumulation of p53, p21 and induction of apoptosis
Muroya et al., Biochim Biophys Acta 1992 (Adrenal Gland Neoplasms...) : K-252a, by contrast, inhibited NGF induced but not EGF dependent activation of ras p21
Nuntharatanapong et al., Am J Physiol Heart Circ Physiol 2005 : EGF receptor dependent JNK activation is involved in arsenite induced p21Cip1/Waf1 upregulation and endothelial apoptosis
Liu et al., Cell Signal 2006 (Carcinoma, Squamous Cell...) : Finally, our experiments utilizing cycloheximide prompt the suggestion that the stability of mRNA or protein also contributes to As2O3- or EGF induced p21 expression ... EGF induced p21 expression may involve similar mechanisms as those that operate in the As2O3 mediated reactions in A431 cells
Paternot et al., Mol Endocrinol 2006 : In primary cultures of normal human thyrocytes, EGF + serum increased cyclin D1 and p21 accumulation, and it stimulated the assembly and activity of cyclin D1-CDK4-p21 complexes
Hu et al., Eur J Nucl Med Mol Imaging 2007 (Breast Neoplasms) : The ability of tat-anti-p21 ( WAF-1/Cip-1 ) to block G ( 1 ) -S phase arrest in MDA-MB-468 cells caused by EGF induced p21 ( WAF-1/Cip-1 ) was evaluated
Beier et al., Atherosclerosis 2008 : To further evaluate downstream effectors of Rac1 stimulation of p21 activated kinase (PAK) and c-Jun N-terminal kinase (JNK) by EGF was determined
Prasad et al., Clin Cancer Res 2012 (Colorectal Neoplasms...) : In addition, ursolic acid suppressed EGF receptor (EGFR) and induced p53 and p21 expression
Kamata et al., Nature 1984 (Cell Transformation, Neoplastic) : We report here the evidence that epidermal growth factor enhances the guanine nucleotide binding activity of activated c-Ha-ras or v-Ha-ras p21, and phosphorylation of v-Ha-ras p21 , suggesting that some mitogenic growth factors may regulate those activities
Decker et al., J Biol Chem 1995 : EGF had little effect on p21Cip1/WAF1 expression in the same parental cells expressing the human EGF receptor
Xie et al., Anticancer Res 1997 (Breast Neoplasms) : The p21WAF1 induction in EGF treated MDA468 cells is probably p53 independent since these cells contain no active p53 ... The sustained rise in p21WAF1 in response to EGF is proposed to be a means of growth inhibition in these cells
Toyoda et al., Biochem Biophys Res Commun 1998 : Involvement of MAP kinase independent protein kinase C signaling pathway in the EGF induced p21 ( WAF1/Cip1 ) expression and growth inhibition of A431 cells ... A broad PKC inhibitor, PKC delta inhibitor, but not the conventional PKC inhibitor suppressed the EGF induced p21 ( WAF1/Cip1 ) expression and the growth inhibition of A431 cells ... These results suggest that PKC, especially PKC delta plays a crucial role in the EGF induced p21 ( WAF1/Cip1 ) expression, resulting in the growth inhibition of A431 cells
Johannessen et al., Biochem J 1999 : Our results indicate that the most important mechanisms by which EGF increases p21/CIP1 protein levels in A431 cells are post-transcriptional and post-translational stabilization