◀ Back to GNB2L1

GNB2L1 — TNF

Pathways - manually collected, often from reviews:

• NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/FAN/NSMASE complex (TNFRSF1A-NSMAF-SMPD2-TNF) → RACK1 (GNB2L1) (modification, collaborate) Tcherkasowa et al., J Immunol 2002
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/FAN/NSMASE complex (TNFRSF1A-NSMAF-SMPD2-TNF) → sTNF-alpha/TNFR1A/FAN/NSMASE/RACK1 complex (TNFRSF1A-NSMAF-SMPD2-GNB2L1-TNF) (modification, collaborate)
  Tcherkasowa et al., J Immunol 2002
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TNF receptor signaling pathway : RACK1 (GNB2L1) → sTNF-alpha/TNFR1A/FAN/NSMASE/RACK1 complex (TNFRSF1A-NSMAF-SMPD2-GNB2L1-TNF) (modification, collaborate)
  Tcherkasowa et al., J Immunol 2002
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Dip Interaction: TNF — GNB2L1 (physical association, pull down) Philipp et al., Proc Natl Acad Sci U S A 2010*
• IRef Dip Interaction: Complex of TNFRSF1A-SMPD3-GNB2L1-EED-TNF (pull down) Philipp et al., Proc Natl Acad Sci U S A 2010*

Text-mined interactions from Literome

Tcherkasowa et al., J Immunol 2002 : Furthermore, activation of N-SMase by TNF was strongly enhanced when RACK1 , FAN, and a noncytotoxic TNF-R55 mutant were expressed concurrently, suggesting RACK1 as a modulator of N-SMase activation
Philipp et al., Proc Natl Acad Sci U S A 2010 : In mammalian cells, TNF causes endogenous EED to translocate from the nucleus and to colocalize and physically interact with both endogenous nSMase2 and RACK1