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MYLIP — TLR4

Text-mined interactions from Literome

Dai et al., Blood 2008 : We found that miR-146a , a negative regulator of Toll-like receptor ( TLR ) signaling, was decreased in freshly isolated splenic lymphocytes from estrogen treated mice compared with placebo controls
Sheedy et al., Ann Rheum Dis 2008 (Arthritis, Rheumatoid...) : Both have multiple targets, with miR-146 inhibiting TLR signalling and miR-155 regulating Th1 cells and also, interestingly, positively regulating mRNA for TNFalpha
Liu et al., Proc Natl Acad Sci U S A 2009 (Inflammation) : TLR4 induced miR-147 expression was both MyD88- and TRIF dependent ... These data demonstrate a negative-feedback loop in which TLR stimulation induces miR-147 to prevent excessive inflammatory responses
Cho et al., J Cell Physiol 2010 (Calcinosis) : Overexpression of miR-146a induced the inhibition of IRAK1 expression and inhibited basal and TNF-alpha- and TLR ligand induced osteogenic differentiation
El Gazzar et al., J Biol Chem 2010 (Inflammation...) : The process required to disrupt protein synthesis followed Toll-like receptor 4 (TLR4) dependent induction of microRNA (miR)-221, miR-579 , and miR-125b, which coupled with RNA binding proteins TTP, AUF1, and TIAR at the 3'-untranslated region to arrest protein synthesis
El Gazzar et al., J Leukoc Biol 2011 (Sepsis) : Here, we used the THP-1 sepsis cell model of bacterial LPS/endotoxin tolerance to show that TLR4 induced miR-146a supports the feed-forward adaptive processes that silence transcription and disrupt translation of acute proinflammatory genes
Hennessy et al., J Biol Chem 2011 : We have found that the putative miR-107 target cyclin dependent kinase 6 (CDK6) expression is increased by TLR4 as a result of the decrease in miR-107
Tarassishin et al., Glia 2011 : Astrocyte miR-155/miR155* were induced by cytokines and TLR ligands with a distinct hierarchy and involved in proinflammatory cytokine gene induction by targeting suppressor of cytokine signaling 1, a negative regulator of cytokine signaling and potentially other factors
Zhao et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2012 : Results showed that miR-21 down-regulated TLR4 at protein levels
Koch et al., Proc Natl Acad Sci U S A 2012 : miR-155 is regulated by Toll-like receptor ( TLR ) ligands in monocyte derived cells and has been shown to be induced in macrophages during H. pylori infection
Wendlandt et al., Innate Immun 2012 : The role of MicroRNAs miR-200b and miR-200c in TLR4 signaling and NF-?B activation
Foley et al., J Leukoc Biol 2012 (Diabetes Mellitus, Type 2...) : The decrease in miR-107 in response to TLR4 may be an attempt to limit insulin resistance, a feature of obesity related inflammation
Bala et al., Journal of translational medicine 2012 (Hepatitis C, Chronic) : Stimulation of normal monocytes with TLR4 and TLR8 ligands or HCV core, NS3 and NS5 recombinant proteins induced a robust increase in both miR-155 expression and TNFa production identifying potential mechanisms for in vivo induction of miR-155 ... Our study suggests that HCV core, NS3, and NS5 proteins or TLR4 and TLR8 ligands can mediate increased miR-155 and TNFa production in chronic HCV infection
Ge et al., Endocrinology 2012 (Inflammation) : miR883b-5p , which is up-regulated by ApN represses LBP and Toll-like receptor-4 signaling, acting therefore as a major mediator of the antiinflammatory action of ApN
Nahid et al., J Immunol 2013 : During bacterial infection, PGN mediated TLR2 signaling induces miR-132/-212 to downregulate IRAK4, an early component in the MyD88 dependent pathway, whereas LPS/TLR4 induced miR-146a downregulates downstream components of the same MyD88 dependent pathway
Lippai et al., PloS one 2013 (Alcoholism...) : TLR4 stimulation with lipopolysaccharide in primary or immortalized mouse microglia resulted in increased miR-155 ... Chronic alcohol induces miR-155 in the cerebellum in a TLR4 dependent manner