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Text-mined interactions from Literome
Bretschneider et al., Br J Pharmacol 1999
:
Activation of
NFkappaB via either
PAR-1 or PAR-2 does not predict mitogenesis
Rahman et al., Circ Res 2002
:
Cotransfection of RGS3T, a regulator of G-protein signaling that inhibits Galpha ( q ), or alpha-transducin ( Galpha ( t ) ), a scavenger of the Gbetagamma, markedly decreased
NF-kappaB activity
induced by
PAR-1 activation ... These results support a model in which ligation of
PAR-1 induces
NF-kappaB activation and ICAM-1 transcription by the engagement of parallel Galphaq/PKC-delta and Gbetagamma/PI3-kinase pathways that converge at Akt
Tantivejkul et al., J Cell Biochem 2005
(Prostatic Neoplasms) :
PAR1 mediated
NFkappaB activation promotes survival of prostate cancer cells through a Bcl-xL dependent mechanism ... Inhibition of p38 and ERK1/2 by SB-203589 and PD-098059, respectively, did not abrogate NFkappaB activity, suggesting an independent
induction of
NFkappaB by
PAR1 stimulation
Syeda et al., J Biol Chem 2006
:
Activation of
PAR-1 or PAR-2 promoted nuclear translocation and phosphorylation of p65-NF-kappaB, and thrombin induced but not PAR-2 induced
p65-NF-kappaB phosphorylation was
reduced by inhibition of MEK or p38MAPK
Lin et al., Arterioscler Thromb Vasc Biol 2006
:
Conversely, small interfering RNA mediated knockdown of KLF2 increases
PAR-1 expression and thrombin mediated
induction of
NF-kappaB activation
Xue et al., Physiol Genomics 2009
:
Here we show that
PAR-1 activation
induces binding of both
p65/RelA and NFATc1 to the NF-kappaB binding site localized in intron-1 of the ICAM-1 gene to initiate transcription in endothelial cells
Gorbacheva et al., Neuroscience 2010
:
Then we investigated whether the binding of APC to
EPCR/PAR-1 is
required to control
NF-kappaB activation
Fujimoto et al., BMC cancer 2010
(Neoplasm Invasiveness...) :
We have shown that activation of
NF-kappaB and EGFR phosphorylation initially were
triggered by the activation of
PAR1 with alpha-thrombin