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Thévenod et al., FASEB J 1999 : Exposure of PT cells with Cd decreased protein levels of the catalytic subunit ( alpha1 ) of Na+/K ( + ) -ATPase , a long lived membrane protein ( t ( 1/2 ) > 48 h ) that drives reabsorption of ions and nutrients through Na ( + ) -dependent transporters in PT. Incubation of PT cells for 48 h with Cd decreased Na+/K(+)-ATPase alpha1-subunit, as determined by immunoblotting, by approximately 50 %, and NAC largely prevented this effect
Munhoz et al., Neuropharmacology 2003 : Na, K-ATPase had a similar activity in control and repeatedly treated animals, but was reduced in the NAc of the acute group
Pascale et al., Toxicol Appl Pharmacol 1989 : S-Adenosyl-L-methionine ( SAM ), L-methionine, and N-acetylcysteine (NAC) , given to rats during ethanol treatment, prevented the decrease in ( Na+, K+ ) ATPase activity and GSH content