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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to APOB

APOB — RHOA

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: APOB → RHOA (increases, APOB Activity)
    Evidence: pitavastatin, a novel HMG Co-A reductase inhibitor, was found to inhibit the expression of apoB48 receptor via inhibition of RhoA. In fact, pretreatment of THP-1 macrophage significantly reduced RLP-induced foam cell formation...

Text-mined interactions from Literome

Zhu et al., Biochim Biophys Acta 2003 : In revealing the mechanism underlying the translocation of eNOS, we found that a high level of LDL increased the level of membrane associated and GTP formed RhoA and activated the RhoA downstream kinase ROCK-1 activity
Sugimoto et al., Cardiovasc Res 2009 : This study was conducted to investigate the role of the LOX-1-MT1-MMP axis in RhoA and Rac1 activation in response to ox-LDL in ECs ... Ox-LDL induced rapid RhoA and Rac1 activation as well as MT1-MMP activity in cultured human aortic ECs ... Inhibition of LOX-1 prevented ox-LDL dependent RhoA and Rac1 activation ... Knockdown of MT1-MMP by small interfering RNA prevented ox-LDL induced RhoA and Rac1 activation, indicating that MT1-MMP is upstream of RhoA and Rac1