◀ Back to EGF

EGF — PLD3

Text-mined interactions from Literome

Hornia et al., Mol Cell Biol 1999 (Cell Transformation, Neoplastic) : Interestingly, both rottlerin and EGF induced substantial increases in phospholipase D ( PLD ) activity, which is commonly elevated in response to mitogenic stimuli
Lu et al., Mol Cell Biol 2000 (Cell Transformation, Neoplastic) : The activation of PLD by EGF in these cells was dependent upon both Ras and RalA
Chen et al., IUBMB Life 2001 : These results indicated that PKC, at least PKC-delta and Ca2+ dependent PKC-alpha or -betaI, plays an important role in BK-induced but not EGF induced PLD activation in A-431 cells
Min et al., Mol Cells 2001 (Carcinoma, Squamous Cell) : Activation of PLD by H2O2 and EGF nearly correlated with tyrosine phosphorylation of the protein in PLD1 immune complexes
Andresen et al., Hypertension 2003 (MAP Kinase Signaling System) : However, EGF stimulation does not activate phospholipase D or generate PA
Lee et al., J Biol Chem 2004 : EGF treatment triggered the dissociation of Munc-18-1 from PLD when PLD was activated by EGF ... The dissociation of the endogenous interaction between Munc-18-1 and PLD, and the activation of PLD by EGF were also observed in primary cultured chromaffin cells
Cook et al., Biochem J 1992 : Pre-treatment of Swiss 3T3 cells with the EGF-receptor tyrosine kinase inhibitor AG18 selectively inhibited EGF stimulated PLD activity ; bombesin stimulated PLD activity was unaffected
Wright et al., Biochem J 1992 : Activation of phospholipase D by alpha-thrombin or epidermal growth factor contributes to the formation of phosphatidic acid, but not to observed increases in 1,2-diacylglycerol ... We investigated the effect of alpha-thrombin and epidermal growth factor (EGF) on cellular PLD activity in order to determine the role of this enzyme in mitogen induced increases in phosphatidic acid and sn-1,2-diacylglycerol ... These data indicate that in quiescent IIC9 cells : ( a ) alpha-thrombin or EGF rapidly and transiently activates a PLD ; ( b ) although this activation is responsible for part of the mitogen induced increases in phosphatidic acid, it does not contribute to induced increases in sn-1,2-diacylglycerol ; and ( c ) activation of this enzyme appears to be involved in the formation of a novel lipid generated in response to alpha-thrombin, but not EGF, in IIC9 fibroblasts
Fisher et al., J Cell Physiol 1991 : To identify the presence of EGF induced phospholipase D activity, cells were labelled with exogenous [ 3H ] 1-0-hexadecyl, 2-acyl phosphatidylcholine and its conversion to phosphatidic acid in response to EGF determined ... Consistent with the presence of EGF induced phospholipase D activity, treatment of cells with EGF, in the presence of [ 14C ] ethanol, resulted in the rapid formation of [ 14C ] phosphatidylethanol, the product of phospholipase D-catalyzed transphosphatidylation
Morrison et al., J Cell Physiol 1995 : Neither basic Fibroblast Growth Factor (bFGF) or Epidermal Growth Factor (EGF) increased PLD activity
Yeo et al., J Biol Chem 1995 : Stimulation of phospholipase D by epidermal growth factor requires protein kinase C activation in Swiss 3T3 cells ... EGF , basic fibroblast growth factor (bFGF), bombesin, and platelet derived growth factor ( PDGF ) activated PLD as measured by transphosphatidylation of butanol to phosphatidylbutanol ... Activation of PLD by EGF was inhibited dose dependently by the PKC inhibitors bis-indolylmaleimide and Ro-31-8220, which also inhibited the effects of bFGF, bombesin, and PDGF ... In summary, all of the results of the study indicate that PLD activation by EGF is downstream of PtdIns ( 4,5 ) P2-hydrolyzing phospholipase and is dependent upon subsequent PKC activation
Dunlop et al., Biochim Biophys Acta 1993 : We investigated the activation of phospholipase D ( PLD ) by a PKC activator, phorbol myristate acetate ( PMA ) and by EGF in CHO cells transfected with the full-length EGF receptor
Budnik et al., FEBS Lett 1993 : We propose, therefore, that phosphatidic acid may act as an intracellular second messenger linking EGF mediated activation of phospholipase D with the sensitization of LH receptor coupled adenylate cyclase signalling system
Mizunuma et al., Biochim Biophys Acta 1993 : The PLD was shown to be activated by phorbol, 12-myristate, 13-acetate ( PMA ), calcium ionophore A23187, oxytocin, bombesin and bradykinin, but not by platelet activating factor (PAF) and epidermal growth factor (EGF)
Kaszkin et al., Biochem J 1996 (Carcinoma, Squamous Cell) : In the case of EGF induced activation of a phospholipase D the amount of phosphatidic acid is only slightly decreased in the presence of a primary alcohol
Hess et al., J Biol Chem 1997 : In response to epidermal growth factor (EGF) , PLD activity was greatly increased in Rat1 fibroblasts expressing wild type Rac1 ( wtRac1 ), and completely abrogated in cells expressing dominant negative N17Rac1, consistent with Rac1 mediating the action of this growth factor ... In summary, these data indicate a major role for Rac1 in the activation of PLD by EGF , but not PDGF or protein kinase C
Zhang et al., Curr Eye Res 1998 : The aim of the present study was to investigate the effect of epidermal growth factor (EGF) on PLD activity in rabbit corneal epithelial cells ( RCEC ) ... Under the same experimental conditions, the inhibitor had no effect on EGF stimulated PLD activity ... Down-regulation of PKC or treatment of the cells with RO31-8220, a PKC inhibitor, inhibited the PMA- but not EGF stimulated PLD activity ... Incubation of the cells with wortmannin, a PI 3-kinase inhibitor, abolished the EGF stimulated PI 3-kinase activity, but potentiated the EGF stimulated PLD activity ... These results indicate that EGF stimulates PLD activity in RCEC by a mechanism that involves tyrosine phosphorylation of a protein ( s ) in the cascade of biochemical reactions initiated by EGF-receptor interaction, and it is not dependent on concurrent activation of PKC, PLC, or PI 3-kinase in these cells
Carpio et al., Prostaglandins Leukot Essent Fatty Acids 1998 (Calcium Signaling) : In summary, PA stimulates rat calvarial osteoblastic cell proliferation and mobilization of [ Ca2+ ] i using extracellular pools, and EGF 's mitogenic effect on these cells requires activation of PLD
Carpio et al., J Bone Miner Res 1998 : This study determined the effects of epidermal growth factor (EGF) on PLD activity in normal rat osteoblastic cells