◀ Back to EPHB2

EPHB2 — SHC1

Text-mined interactions from Literome

Hashimoto et al., J Biol Chem 1999 : Here we show that the EGF mediated ERK activation is abolished by loss of Grb2, whereas this response is not affected by loss of Shc ... These findings strongly support distinct roles for Grb2 and Shc in controlling ERK and JNK activation after EGF stimulation
Lennartsson et al., Oncogene 1999 (MAP Kinase Signaling System) : In a mutant receptor with both Tyr568 and Tyr570 mutated to phenylalanine residues, no phosphorylation of Shc and no activation of Ras and Erk2 was seen in response to stem cell factor stimulation, very weak induction of c-fos was seen and the mitogenic response was severely depressed
Goi et al., EMBO J 2000 : In contrast, c-Src activated by isoproterenol led to tyrosine phosphorylation of Shc and subsequent Erk activation , but not tyrosine phosphorylation of cortactin or Stat3
Goetze et al., J Biol Chem 2000 : Insulin binding to the insulin receptor (IR) triggers its autophosphorylation, resulting in phosphorylation of Shc and the downstream activation of p42/p44 extracellular signal regulated kinase 1/2 mitogen activated protein kinase ( ERK1/2 ), which mediates insulin induced proliferation in vascular smooth muscle cells ( VSMC ) ... Thus, TNFalpha selectively interferes with insulin induced mitogenic signaling by inhibiting the phosphorylation of Shc and the downstream activation of ERK1/2
Caverzasio et al., J Bone Miner Res 2000 : In contrast to their implication in epidermal growth factor (EGF) receptor tyrosine kinase signaling, the adaptor protein Shc , the Grb2/Sos complex, and the small G protein Ras were not involved in the activation of Erk induced by either LPA or PGF2alpha in MC3T3-E1 cells, suggesting that activation of Erk by Gi and Gq protein coupled receptors is Ras independent in these cells
Kurihara et al., Endocr J 2000 (Neuroblastoma) : PD98059 inhibited activation of Erk and LY294002 repressed activation of Akt in response to IGF-I, but did not affect tyrosine phosphorylation of the IGF-IR, IRS-1, IRS-2, or Shc
Frantsve et al., Mol Cell Biol 2001 (Cell Transformation, Neoplastic) : TEL-JAK2, in addition to activating Stat5, associates with Shc and Grb2 and induces activation of Erk2 , and expression of Socs-1 inhibits engagement of each of these signaling molecules
Zhen et al., Mol Pharmacol 2001 : Moreover, PP2 ( 20 nM ), an inhibitor of Src, blocked D ( 4 ) receptor mediated SHC phosphorylation and ERK activation
Slevin et al., J Biol Chem 2002 : Binding of Src to Shc was required for its activation and for Ras dependent activation of ERK1/2 , cell proliferation, and wound recovery
Rakatzi et al., Diabetes 2003 (MAP Kinase Signaling System) : This finding correlated with a prominent Shc/IGF-I receptor interaction, tyrosine phosphorylation of Shc , activation of extracellular signal regulated protein kinase ( ERK ) -1 and -2, and stimulation of DNA synthesis by HMR 1153 and Asp ( B10 ) insulin
Faisal et al., J Biol Chem 2004 : Non-redundant role of Shc in Erk activation by cytoskeletal reorganization
Schäfer et al., Oncogene 2004 (Neoplasm Invasiveness...) : Our results show that GPCR ligands induce tyrosine phosphorylation of the epidermal growth factor receptor (EGFR) as well as downstream signalling events such as recruitment of the adapter protein Shc and activation of the mitogen activated protein kinases ( MAPK) ERK1/2 , JNK and p38
Kawabe et al., Am J Physiol Heart Circ Physiol 2004 : Taken together, caveolin in caveolae may keep ERK inactive, but when caveolin is translocated to noncaveolar sites in response to stretch stress, caveolin mediates stretch induced ERK activation through an association with beta1-integrins/Fyn/Shc
Shiraishi et al., Endocrinology 2006 : Because a dominant negative mutant of Shc inhibits the LHR mediated activation of Ras and the phosphorylation of ERK1/2 , we conclude that the LHR mediated phosphorylation of ERK1/2 is mediated, at least partially, by the classical pathway used by growth factor receptors
Kleiner et al., FEBS J 2007 (MAP Kinase Signaling System) : Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc dependent Erk signaling
Kraut-Cohen et al., J Biol Chem 2008 (Breast Neoplasms...) : PTPepsilon binds and dephosphorylates Shc in vivo, reducing the association of Shc with Grb2 and inhibiting downstream ERK activation
Cursio et al., Langenbecks Arch Surg 2009 (Reperfusion Injury) : Shc tyrosine phosphorylation and activation of ERK1/2 were increased after reperfusion, while tyrosine phosphorylation of IRS-1 and activation of PKB/Akt were decreased
Ginés et al., J Biol Chem 2010 (Huntington Disease...) : Impaired TrkB mediated ERK1/2 activation in huntington disease knock-in striatal cells involves reduced p52/p46 Shc expression
Fabbrocini et al., Exp Dermatol 2010 (MAP Kinase Signaling System) : Finally, we showed that resveratrol induced p66Shc-Ser36 phosphorylation is dependent on ERK1/2 activation
Suen et al., Nature structural & molecular biology 2013 : Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli ... Thus, in addition to its established role in promoting MAP kinase signaling in stimulated cells, Shc negatively regulates Erk activation in the absence of growth factors and thus could be considered a tumor suppressor in human cells
Xiong et al., Journal of the American Heart Association 2013 : Conversely, silencing p66Shc reduced ERK and S6K1 signaling and Arg-II levels and cell senescence/apoptosis
Van der Zon et al., Biochemistry 1996 : We have examined whether this specific Tyr residue contributes to the generation of TK-specific responses, such as Tyr phosphorylation of Shc , activation of Ras and Erk1,2 , and stimulation of DNA synthesis
Kao et al., Endocrinology 1997 : In contrast, expression of the MAP kinase phosphatase ( MKP-1 ) completely prevented ERK activation but did not inhibit the serine phosphorylation of 66-kDa Shc
Mainiero et al., EMBO J 1997 : While the stimulation of Erk by alpha6beta4 was suppressed by dominant negative Shc , Ras and RhoA, the activation of Jnk was inhibited by dominant negative Ras and Rac1 and by the phosphoinositide 3-kinase inhibitor Wortmannin
Chen et al., J Biol Chem 1998 : Calcitonin induced time- and concentration dependent increases in Shc tyrosine phosphorylation, Shc-Grb2 association and Erk1/2 phosphorylation and activation in a HEK 293 cell line that stably expresses the rabbit calcitonin receptor C1a isoform
Chen et al., Mol Cell Biol 1998 : The arsenite induced tyrosine phosphorylation of Shc, enhancement of Shc and Grb2 interactions, and activation of ERK were all drastically reduced by treatment of cells with either the general growth factor receptor poison suramin or the EGFR-selective inhibitor tyrphostin AG1478