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CHKA — EPHB2

Text-mined interactions from Literome

Pei et al., Mol Pharmacol 2006 (Multiple Myeloma) : They also suggest a role for Chk1 in UCN-01 induced ERK1/2 activation, implying the existence of a heretofore unrecognized link between Chk1 and ERK1/2 signaling
Chou et al., Food Chem Toxicol 2007 (Colonic Neoplasms) : These results imply that ERK1/2 mediated Chk1 activation may be play an important role in determining TUBU induced G2/M arrest or apoptosis in COLO 205 cells
Sidorova et al., Pharm Res 2008 : Using phosphorylation site-specific antibodies, we demonstrated that lindane, dieldrin, and ChK all activated p44/42 ERK , but only ChK activated Akt kinase
Mitchell et al., Mol Pharmacol 2010 : Prior studies have demonstrated that inhibition of CHK1 can promote the activation of extracellular signal regulated kinases 1 and 2 ( ERK1/2 ) and phosphorylation of histone H2AX and that inhibition of poly(ADP-ribose) polymerase 1 ( PARP1 ) can affect growth factor induced ERK1/2 activation