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IL12B — IL3
Text-mined interactions from Literome
La Flamme et al., PloS one 2012
:
Instead, we found that derivation culture conditions ( GM-CSF plus IL-3 versus M-CSF ) could explain the different responses of BALB/c and IL-4Ra-/- macrophages, and these cytokines shaped the ensuing macrophage such that GM-CSF plus
IL-3 promoted more
IL-12 and IL-4 while M-CSF led to higher IL-10 production
Ploemacher et al., Leukemia 1993
:
In
IL-3 + SF-containing cultures,
IL-12 further
increased colony numbers and a higher percentage of colonies expressed neutrophilic, megakaryocytic, erythroid, monocytic, blast cell, and/or mast cell lineages
Ploemacher et al., Leukemia 1993
:
Previous data have shown that
IL-12 may act as a potent synergistic factor stimulating multilineage expression of hemopoietic stem cells in the
presence of
IL-3 in combination with Steel factor ( SF ) or IL-11
Hegde et al., Cell Immunol 1995
(Neoplasms, Experimental) :
AK-5 tumor
induced expression of
interleukin-12 : role of
IL-12 in NK-mediated AK-5 regression
Quelle et al., Mol Cell Biol 1995
:
In contrast, IL-2,
IL-3 , and erythropoietin
induce the tyrosine phosphorylation of Stat5 while
IL-12 uniquely induces the tyrosine phosphorylation of Stat4
Morris et al., J Immunol 1994
:
In untreated mice
IL-12 enhanced IFN-gamma and IL-10 gene expression and protein secretion,
reduced base line
IL-3 and IL-4 gene expression, and increased serum IgG2a concentration
Finkelman et al., J Exp Med 1994
(Intestinal Diseases, Parasitic...) :
IL-12 stimulated IFN-gamma and IL-10 gene expression during primary and secondary N. brasiliensis infections and
inhibited IL-3 , IL-4, IL-5, and IL-9 gene expression during primary infections but had little inhibitory effect during secondary infections