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NOX5 — SREBF1

Text-mined interactions from Literome

Ishigaki et al., Biochem Biophys Res Commun 2007 (Diabetes Mellitus, Experimental...) : Gene expression of P47phox, p67phox, and PU.1 were also activated, accompanying increased 8-OHdG in urine and kidney, demonstrating that glomerular SREBP-1c could directly cause oxidative stress through induced NADPH oxidase
Huang et al., Mol Cancer Res 2012 (Carcinoma...) : In this article, we provide a new finding that SREBP-1 induced oxidative stress in prostate cancer cells through increased production of reactive oxygen species ( ROS ) and expression of NADPH oxidase 5 (Nox5) ... We have shown that ( i ) expression of SREBP-1 protein is positively associated with the clinical Gleason grades in human prostate cancer ; ( ii ) genetic overexpression or knockdown of SREBP-1 in prostate cancer cells resulted in corresponding increased or decreased AR, FASN and Nox5 expression, fatty acid and lipid droplet accumulation, and ROS generation ; and ( iii ) SREBP-1 induces and promotes the growth, migration, invasion, and castration-resistant progression of prostate cancer cells in vitro and in vivo