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NOTCH1 — SOX2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Bani-Yaghoub et al., Dev Biol 2006
:
Overexpression of constitutively active
Sox2 in neural progenitors
resulted in upregulation of
Notch1 , recombination signal-sequence binding protein-J ( RBP-J ) and hairy enhancer of split 5 (Hes5) transcripts and the Sox2 high mobility group ( HMG ) domain seemed sufficient to confer these effects
Dabdoub et al., Proc Natl Acad Sci U S A 2008
:
Sox2 expression is
promoted by
Notch signaling and Prox1, a homeobox transcription factor, is a downstream target of Sox2
Genethliou et al., Biochem Biophys Res Commun 2009
:
We show that,
SOX1 expression in the vSC is
regulated by PAX6, NKX2.2 and
Notch signalling in a domain-specific manner
Ehm et al., J Neurosci 2010
:
Interestingly, we found that
Notch signaling
increases Sox2 promoter activity and Sox2 expression in adult neural stem cells
Zakharova et al., PloS one 2012
:
In c-Kit+ cells, Notch stimulation reduced, while
Notch inhibition
up-regulated pluripotency marker expressions such as Nanog and
Sox2
Matsuda et al., J Neurosci 2012
:
The High Mobility Group ( HMG ) -box transcription factor,
Sox2 , and the cell surface
activated transcriptional regulator,
Notch , play important roles in CNS stem cells