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MAFA — MAPK7
Text-mined interactions from Literome
Kondo et al., Mol Endocrinol 2009
(Hyperglycemia) :
We demonstrate that
MafA protein stability in MIN6 cells and isolated mouse islets is
regulated by both p38
MAPK and glycogen synthase kinase 3
El Khattabi et al., Mol Endocrinol 2013
:
We show that under oxidative and nonoxidative conditions p38
MAPK directly binds to MafA and
triggers MafA degradation via ubiquitin proteasomal pathway ... These results identify two distinct pathways mediating p38
MAPK dependent
MafA degradation under oxidative and nonoxidative conditions and show that inhibiting MafA degradation under oxidative stress ameliorates ß-cell dysfunction and could lead to novel therapies for diabetes