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IL2RG — STAT5A
Pathways - manually collected, often from reviews:
-
BioCarta il-7 signal transduction:
IL-7/IL-7Ra/IL-2R-gamma/JAK1/JAK3 complex (ITGA2B-Il7r-IL2RG-JAK1-JAK3)
→
STAT5 (STAT5A/STAT5B)
(modification, activates)
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
Nmi/STAT5 complex (NMI-STAT5A_STAT5B)
(modification, activates)
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
STAT5 (STAT5A/STAT5B)
(modification, activates)
Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
STAT5 (dimer)-active (STAT5B/STAT5A)
(modification, activates)
Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
-
NCI Pathway Database IL2 signaling events mediated by STAT5:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
→
STAT5 (dimer)-active (STAT5B/STAT5A)
(transcription, activates)
Moriggl et al., Immunity 1999, Brennan et al., Immunity 1997
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL4-mediated signaling events:
STAT5 (STAT5A/STAT5B)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Mora et al., J Immunol 2001
Evidence: mutant phenotype, physical interaction, other species
-
Reactome Reaction:
IL2RG
→
STAT5A
(indirect_complex)
Johnston et al., Proc Natl Acad Sci U S A 1995, Lin et al., J Biol Chem 1996, Gaffen et al., J Biol Chem 1996
-
Reactome Reaction:
IL2RG
→
STAT5A
(reaction)
Johnston et al., Proc Natl Acad Sci U S A 1995, Lin et al., J Biol Chem 1996, Gaffen et al., J Biol Chem 1996, Behrmann et al., J Biol Chem 1997
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Yao et al., Proc Natl Acad Sci U S A 2006
:
Thus, deficiency of
Stat5 results in
severe combined immunodeficiency , similar in many respects to deficiency of IL-7R, gammac, and Jak3
Amorosi et al., J Immunol 2009
(X-Linked Combined Immunodeficiency Diseases) :
The reduction of
gamma(c) protein expression also
reduced GH-induced proliferation and
STAT5 nuclear translocation in B lymphoblastoid cell lines
Rolling et al., FEBS Lett 1996
:
We show that as in the IL4R complex, both IL4R alpha and IL2R
gamma c are components of the IL13R and that both cytokines
induced STAT6, STAT3 and
STAT5 activation in B cells