Cedazo-Mínguez et al., Neurochem Int 2001
(Neuroblastoma) :
Effects of apolipoprotein E (apoE) isoforms, beta-amyloid ( Abeta ) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts ... We investigated the effects of different apolipoprotein E (apoE) isoforms, Abeta ( 1-42 ), and apoE/Abeta complexes on PKC-alpha translocation and APP processing in human SH-SY5Y neuroblastoma cells and fibroblasts
Cedazo-Mínguez et al., J Neurochem 2003
(Neuroblastoma) :
ApoE4 also activated PKC-alpha and PKB possibly giving the subsequent GSK-3beta inhibition