Su et al., J Biol Chem 2006
:
TRPM7 regulates cell adhesion by controlling the calcium dependent protease calpain Yogi et al., Am J Physiol Regul Integr Comp Physiol 2009
:
Our data demonstrate that in bradykinin stimulated VSMCs : 1 ) TRPM7 is upregulated, 2 ) TRPM7 associates with cholesterol-rich microdomains, and 3 ) calpain and proinflammatory mediators VCAM-1 and COX2 are regulated , in part, via TRPM7- and phospholipase C-dependent pathways through B2 receptors
Su et al., J Mol Biol 2010
(MAP Kinase Signaling System) :
Application of inhibitors of p38 MAPK and JNK blocked TRPM7 induced cell rounding and activation of m-calpain , without affecting the phosphorylation state of the protease