Liu et al., J Biol Chem 2005
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Moreover, previous studies have demonstrated that the Kruppel-like transcription factor ( KLF) 4 potently represses the expression of multiple SMC genes
Fujiu et al., Circ Res 2005
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Knocking down KLF5 using small interfering RNA suppressed serum induced downregulation of SMC differentiation marker gene expression in cultured SMCs, and haploinsufficiency of KLF5 in mice attenuated phenotypic modulation of SMCs after vascular injury, indicating that KLF5 plays a key role in the control of SMC phenotype