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AKT3 — PTK7

Text-mined interactions from Literome

Kue et al., J Urol 2000 (Prostatic Neoplasms) : Whereas activation of Akt by these stimuli is not dependent on protein tyrosine kinase activation, it is mediated by PI3K
Sengupta et al., Arterioscler Thromb Vasc Biol 2003 (MAP Kinase Signaling System...) : PTK787 inhibited the VEGF induced activation of Akt and ERKs, without affecting the HGF/SF induced phosphorylation
Liu et al., Lab Invest 2009 (Disease Models, Animal...) : PTK/ZK also induced cell cycle arrest, accompanied by increasing the expression of p27 ( Kip1 ) and downregulation of cyclin D1 and cyclin E. PTK/ZK significantly inhibited vascular endothelial growth factor ( VEGF ) expression, as well as VEGF simulated cell proliferation and phosphorylation of Akt in activated HSCs
Liu et al., Lab Invest 2009 (Liver Cirrhosis) : We provide evidence that PTK787/ZK222584 ( PTK/ZK ) , a potent tyrosine kinase inhibitor that blocks vascular endothelial growth factor receptor ( VEGFR ), significantly inhibits PDGF receptor expression, as well as PDGF simulated HSC proliferation, migration and phosphorylation of ERK1/2, Akt and p70S6 kinase
Zheng et al., Mol Cell Biol 2010 : Our data indicate that in addition to promoting growth factor receptor mediated activation of AKT, PTK6 can directly activate AKT to promote oncogenic signaling
Weidenaar et al., Mol Cancer Res 2013 (Leukemia, Myeloid, Acute...) : Proteome profiler array analysis of downstream kinases revealed that PTK/ZK reduced activation of PI3K/Akt kinase signaling