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IL2 — PKD2

Text-mined interactions from Literome

Irie et al., Int Immunol 2006 : Expression of WT-PKD2 enhanced IL-2 promoter activity upon stimulation with anti-CD3 mAb, while expression of CA-PKD2 inhibited IL-2 promoter activity and induced cell death ... The data provide a renewing insight into the subset of PKD family kinases expressed in T cells and suggest that PKD2 is involved in IL-2 promoter regulation and cell death depending on its activity upon TCR stimulation
Irie et al., PloS one 2012 : We previously reported that protein kinase D2 (PKD2) in T cells is promptly activated after T-cell receptor ( TCR ) stimulation and involved in the activation of interleukin-2 promoter and T cell death, and that one of its candidate substrate is SET protein, a natural inhibitor for protein phosphatase 2A (PP2A)