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GSK3B — IL10
Text-mined interactions from Literome
Lambert et al., J Immunol 2007
:
We find that
GSK3beta regulates LMP1 dependent
IL-10 induction, with GSK3beta inhibition by pharmacologic or small interfering RNA strategies enhancing LMP1 induced IL-10 induction
Zhang et al., Mol Immunol 2009
(Disease Models, Animal...) :
Inhibition of
GSK3beta resulted in a significant decrease in the production of pro-inflammatory cytokine IL-6, IL-12p40 and TNF-alpha, as well as a significant increase in the production of the anti-inflammatory cytokine
IL-10
Garcia et al., J Immunol 2008
:
Rather we find that
GSK3beta plays a previously unrecognized role in the selective regulation of the
IL-10 recall response by human memory CD4 ( + ) T cells
Cheng et al., Infect Immun 2009
(Inflammation) :
These results suggest that
GSK-3beta regulates heat inactivated S. aureus induced TNF-alpha and NO production in microglia mainly by activating NF-kappaB and probably by inhibiting
IL-10
Garcia et al., J Immunol 2009
:
The ability of IL-12p70 to inactivate
GSK3beta and induce c-jun levels was
required for IL-12 to augment
IL-10 production by human memory CD4+ T cells, since small interfering RNA mediated gene silencing of c-jun abrogated this process