◀ Back to STAT1

PDGFRB — STAT1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: STAT1 → Complex of PDGFRB-PDGFRB (directlyIncreases, PDGFRB/PDGFRB Activity) Heldin et al., Physiol Rev 1999
  Evidence: I. Stat The family of Stat molecules has seven members of which Stat1, Stat3, Stat5a and -beta , and Stat6 have been shown to bind to the activated PDGF beta -receptor and to be phosphorylated after PDGF stimulation; binding also occurs to the alpha -receptor, albeit only weakly (347, 474, 482). After phosphorylation on tyrosine, Stats dimerize and translocate to the nucleus, where they act as transcription factors (reviewed in Ref. 92). Stat molecules are important for the transduction of signa...
• Reactome Reaction: PDGFRB → STAT1 (indirect_complex) Vignais et al., Mol Cell Biol 1996, Valgeirsdóttir et al., Oncogene 1998, Heldin et al., Biochim Biophys Acta 1998
• Reactome Reaction: PDGFRB → STAT1 (reaction) Vignais et al., Mol Cell Biol 1996, Valgeirsdóttir et al., Oncogene 1998, Heldin et al., Biochim Biophys Acta 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: PDGFRB — STAT1 (in vivo) Yamamoto et al., Exp Cell Res 1996*, Valgeirsdóttir et al., Oncogene 1998
• IRef Hprd Interaction: PDGFRB — STAT1 (in vitro) Yamamoto et al., Exp Cell Res 1996*, Valgeirsdóttir et al., Oncogene 1998
• IRef Intact Interaction: PDGFRB — STAT1 (physical association, proximity ligation assay) Liu et al., Mol Cell Proteomics 2013

Text-mined interactions from Literome

Vignais et al., Mol Cell Biol 1999 : Using purified recombinant STAT proteins produced in Escherichia coli, we found that Stat1 could be activated by immunopurified PDGFR and showed no additional requirement for membrane- or cytosol derived proteins
Kim et al., BMC cancer 2011 (Leukemia...) : Stat1 and Gbp1 were induced uniquely by TEL-PDGFRB