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BRCA1 — EPHB2

Text-mined interactions from Literome

Razandi et al., Mol Cell Biol 2004 (Breast Neoplasms) : The proliferation of MCF-7 cells induced by E2 was significantly inhibited by PD98059, a specific ERK inhibitor , or by dominant negative ERK2 expression and by expression of wt BRCA1 ( but not mutant BRCA1 )
Yan et al., Oncogene 2005 (Breast Neoplasms) : We have recently shown that ectopic expression of BRCA1 in MCF-7 human breast cancer cells resulted in activation of extracellular signal regulated protein kinase 1 and 2 ( ERK1/2 ) and G2/M cell cycle arrest ... Furthermore, inhibition of BRCA1 induced ERK1/2 activation using mitogen activated protein kinase kinase 1 and 2 ( MEK1/2 ) -specific inhibitors resulted in increased apoptosis, suggesting a potential role of ERK1/2 kinases in BRCA1 mediated G2/M checkpoint response ... Results indicate that BRCA1 induced G2/M cell cycle arrest and ERK1/2 activation correlate with changes in the level and/or activity of several key regulators of the G2/M checkpoint, including activation of Chk1 and Wee1 kinases, induction of 14-3-3, and down-regulation of Cdc25C
Yan et al., Cancer Res 2008 : Studies using short hairpin RNA targeting BRCA1 show that BRCA1 expression is necessary for IR-induced G ( 2 ) -M cell cycle arrest, as well as ERK1/2 activation in MCF-7 cells