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APPL1 — EPHB2

Text-mined interactions from Literome

Lee et al., Biochemistry 2008 (MAP Kinase Signaling System) : Downregulation of APPL1 , an adapter protein and putative mediator of AdipoR1/R2 signaling, impaired adiponectin stimulated ERK1/2 activation
Wang et al., Diabetes 2011 (Insulin Resistance...) : In endothelial cells, APPL1 potentiated insulin stimulated Akt activation by competing with the Akt inhibitor Tribbles 3 (TRB3) and suppressed ERK1/2 signaling by altering the phosphorylation status of its upstream kinase Raf-1 ... In endothelial cells, APPL1 potentiated insulin stimulated Akt activation by competing with the Akt inhibitor Tribbles 3 (TRB3) and suppressed ERK1/2 signaling by altering the phosphorylation status of its upstream kinase Raf-1