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AKT1 — PLD6
Text-mined interactions from Literome
Wang et al., Biochem Pharmacol 2003
:
Collectively, these results indicate that the inhibition by CCY1a of fMLP induced O2 ( .- ) generation in rat neutrophils can probably be attributed to the increase in cAMP levels, and to the blockade of Ca2+ entry, suppression of
Akt , and
PLD activation via cAMP independent mechanisms
Kam et al., FASEB J 2004
:
PDGF induced marked phosphorylation of
Akt ( a PI3K target ) but this was not
affected by
PLD deficiency ... LPA caused much less phosphorylation of
Akt and this was
dependent on
PLD activity
Li et al., J Pharmacol Exp Ther 2005
:
Diacylglycerol kinase inhibitor II diminished Ang II-induced and diC8-phosphatidic acid ( PA ) -increased Akt phosphorylation, suggesting that
PLD dependent
Akt activation is mediated by PA
Kim et al., Cancer Res 2006
:
Etoposide induced activation of
Akt was
potentiated by overexpression of
PLD and PLD stimulated suppression of Egr-1 was blocked by inhibition of phosphatidylinositol 3-kinase/Akt survival pathway at the both transcriptional and posttranscriptional levels
Condliffe et al., J Immunol 2006
:
Additionally, fMLP stimulated phosphorylation of
protein kinase B and p38MAPK,
activation of
phospholipase D , and calcium fluxes were equivalent in wild-type and RhoG ( -/- ) neutrophils
Toschi et al., Mol Cell Biol 2009
:
Suppression of
PLD also
blocked insulin stimulated
Akt phosphorylation at Ser473 and the mTORC2 dependent phosphorylation of PRAS40