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AHR — CUL4B

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS CORUM Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1): Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1) complex (AHR-ARNT-CUL4B-DDB1-RBX1-TBL3) Ohtake et al., Nature 2007
• IRef Corum Interaction: Complex of ARNT-AHR-RBX1-TBL3-CUL4B-DDB1 (association, anti tag coimmunoprecipitation) Ohtake et al., Nature 2007
• IRef Dip Interaction: Complex of DDB1-CUL4B-AHR-CTNNB1 (anti bait coimmunoprecipitation) Kawajiri et al., Proc Natl Acad Sci U S A 2009*
• IRef Hprd Interaction: Complex of 37 proteins (in vivo) Ohtake et al., Nature 2007
• IRef Hprd Interaction: AHR — CUL4B (in vivo) Ohtake et al., Nature 2007

Text-mined interactions from Literome

Ohtake et al., Nature 2007 : In the CUL4B ( AhR ) complex, ligand activated AhR acts as a substrate-specific adaptor component that targets sex steroid receptors for degradation
Ohtake et al., Biochem Pharmacol 2009 : In the CUL4B ( AhR ) complex, AhR acts as a substrate-recognition subunit to recruit ERalpha/AR