Gene interactions and pathways from curated databases and text-mining

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ICAM1 — NOS2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Zadeh et al., J Leukoc Biol 2000 : Regulation of ICAM-1/CD54 expression on human endothelial cells by hydrogen peroxide involves inducible NO synthase
Hierholzer et al., Am J Physiol Gastrointest Liver Physiol 2004 (Enteritis...) : Selective iNOS inhibition in shocked animals reduced the binding activity of NF-kappaB and Stat3 and reduced mRNA levels of ICAM-1 , IL-6, and G-CSF
Look et al., J Immunol 2005 : The thiol antioxidant N-acetyl cysteine, extracellular catalase, and inducible NO synthase inhibitors inhibited ICAM-1 and IL-8 increases in response to both phenazines
Martinelli et al., Mol Biol Cell 2009 : ICAM-1 mediated endothelial nitric oxide synthase activation via calcium and AMP activated protein kinase is required for transendothelial lymphocyte migration
Lu et al., Environ Toxicol Pharmacol 2012 (Drug-Induced Liver Injury) : The expressions of ICAM-1 , vimentin, prohibitin, HGF, c-MET and GSTA1 were also regulated by dioscin and iNOS was also involved in the effects of this agent
Ning et al., PloS one 2013 (Inflammation...) : In addition, NaHS treatment prevented the increase of nitric oxide, Intercellular Adhesion Molecule 1 ( ICAM-1 ) and interleukin (IL)-6 production and inducible nitric oxide synthase activation induced by TNF-a
Fukuzawa et al., Immunol Lett 1997 : Nicotinamide, a pellagra-preventive factor, has multiple functions such as inhibition of poly-ADP-ribose synthetase, inhibition of inducible nitric oxide synthase , free radical scavenging and suppression of major histocompatibility complex class II expression and ICAM-1 expression on endothelial cells