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CD44 — HGF
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Fujisaki et al., Cancer Res 1999
(Colonic Neoplasms) :
Our results showed the following novel features of CD44 on the cells : ( a ) colon cancer cells express high levels of CD44 ; ( b ) stimulation of cancer cells by CD44 cross linking or fragmented hyaluronan markedly induces the expression of LFA-1s, some of which reveal an activation epitope on the cells ; ( c ) CD44 cross linking induces F-actin polymerization in the cell cortex ; ( d ) fragmented hyaluronan induces up-regulation of the activation epitope of LFA-1, which is mediated through protein kinase C ; ( e ) stimulation of CD44 augments the LFA-1 mediated adhesion of cancer cells to endothelial cells and intercellular adhesion molecule 1-transfected cells and facilitates transendothelial migration ; ( f ) stimulation of
CD44 also
induces expression of the hepatocyte growth factor (HGF) receptor c-Met on cancer cells ; and ( g )
HGF further amplifies the LFA-1 mediated adhesion of cells prestimulated by CD44 derived signaling
Shimabukuro et al., Gynecol Oncol 2001
(Adenocarcinoma...) :
To investigate the mechanism of an inductive effect of HGF/SF on the invasiveness of SKG-IIIa, we examined the
effect of
HGF/SF on the expression of intercellular adhesion molecule E-cadherin, cell-substrate adhesion molecules
CD44 , alpha2beta1, and alpha6beta1, and intracellular skeleton fiber actin in SKG-IIIa in cell enzyme linked immunosorbent assay ( ELISA ) and immunofluorescence staining
Mine et al., Exp Cell Res 2003
(Breast Neoplasms) :
( 2 ) the maximum level of
HGF induced
CD44 up-regulation on breast cancer cell lines occurred within 3 h. ( 3 ) HGF induced up-regulation of CD44 was mediated by the tyrosine kinase signaling pathway
Singleton et al., J Biol Chem 2007
(Atherosclerosis...) :
We observed that
HGF promoted c-Met association with
CD44v10 and recruitment of c-Met into caveolin enriched microdomains ( CEM ) containing CD44s ( standard form )
Ghatak et al., J Biol Chem 2010
(Neoplasm Invasiveness...) :
Our results now show that
hepatocyte growth factor synthesized by myofibroblasts associated with prostate cancer cells induces activation of HGF-receptor/cMet and
stimulates hyaluronan/CD44v9 signaling ... The stroma derived
HGF induces a lipid raft associated signaling complex that contains
CD44v9 , cMet/phosphatidylinositol 3-kinase, HSP90 and androgen receptor
Damm et al., J Invest Dermatol 2010
(Lymphatic Metastasis...) :
HGF dependent
CD44v6 regulation in melanocytes is NF-kappaB dependent because BAY 11-7082, an inhibitor of NF-kappaB activation, but not interference with the mitogen activated protein kinase or phosphatidylinositol 3-kinase cascade, antagonized HGF induced CD44v6 expression
Locatelli et al., J Biol Chem 2011
(Neoplasm Metastasis) :
We sought to further understand how
HGF regulates
CD44v5 expression ...
HGF stimulated
CD44v5 protein expression and HaCaT cell migration ; these events required activation of the ERK1/2 MAPK module and Sam68, a protein involved in RNA processing, splicing, and v5 inclusion
Hiscox et al., Biochem Biophys Res Commun 1997
(Neoplasm Metastasis...) :
Regulation of endothelial
CD44 expression and endothelium-tumour cell interactions by
hepatocyte growth factor/scatter factor ... Addition of anti-CD44 antibodies in this assay inhibited the effects of HGF/SF. Western blotting studies showed that
HGF/SF increased expression of the adhesion molecule
CD44 in endothelial cells