◀ Back to TP53
TAF1 — TP53
Pathways - manually collected, often from reviews:
-
BioCarta hypoxia and p53 in the cardiovascular system:
TFIID/RPA/JNK/p300/p53 complex (TAF1-RPA1-MAPK8-EP300-TP53)
→
Mdr1b (ABCB1)
(transcription, activates)
-
BioCarta hypoxia and p53 in the cardiovascular system:
TFIID/RPA/JNK/p300/p53 complex (TAF1-RPA1-MAPK8-EP300-TP53)
→
BAX
(transcription, activates)
-
BioCarta hypoxia and p53 in the cardiovascular system:
TFIID/RPA/JNK/p300/p53 complex (TAF1-RPA1-MAPK8-EP300-TP53)
→
GADD45A
(transcription, activates)
-
BioCarta hypoxia and p53 in the cardiovascular system:
TFIID/RPA/JNK/p300/p53 complex (TAF1-RPA1-MAPK8-EP300-TP53)
→
FHL2
(transcription, activates)
-
BioCarta hypoxia and p53 in the cardiovascular system:
TFIID/RPA/JNK/p300/p53 complex (TAF1-RPA1-MAPK8-EP300-TP53)
→
p21 (CDKN1A)
(transcription, activates)
-
BioCarta hypoxia and p53 in the cardiovascular system:
TFIID/RPA/JNK/p300/p53 complex (TAF1-RPA1-MAPK8-EP300-TP53)
→
IGFBP3
(transcription, activates)
-
BioCarta hypoxia and p53 in the cardiovascular system:
TFIID/RPA/JNK/p300/p53 complex (TAF1-RPA1-MAPK8-EP300-TP53)
→
p53 (TP53)
(modification, collaborate)
-
BioCarta hypoxia and p53 in the cardiovascular system:
TFIID/RPA/JNK/p300/p53 complex (TAF1-RPA1-MAPK8-EP300-TP53)
→
TFIID/RPA/JNK/p300 complex (TAF1-RPA1-MAPK8-EP300)
(modification, collaborate)
-
BioCarta hypoxia and p53 in the cardiovascular system:
p53 (TP53)
→
TFIID/RPA/JNK/p300 complex (TAF1-RPA1-MAPK8-EP300)
(modification, collaborate)
-
FastForward regulation:
TAF1
→
TP53
(transcriptional regulation, unknown)
Kim et al., Nature 2005
Evidence: DNABINDING
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Li et al., Mol Cell 2004
(Bone Neoplasms) :
We found that
TAF1 induces G1 progression in a
p53 dependent manner
Li et al., Mol Cell 2007
:
Disruption of
acetyl-p53/bromodomain interaction
inhibits TAF1 recruitment to both the distal p53 binding site and the core promoter
Li et al., Mol Cell 2009
:
We further demonstrate that
MOF-MSL1v1 is specifically
required for optimal transcription activation of
p53 target genes both in vitro and in vivo
Chen et al., Genes Dev 1993
:
Surprisingly, both TBP and
TFIID also
stimulate p53 binding to DNA containing a specific p53 binding site but lacking a TATA box