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BHLHE40 — TP53

Pathways - manually collected, often from reviews:

• FastForward regulation: TP53 → BHLHE40 (transcriptional regulation, increase) Qian et al., J Biol Chem 2008*
  Evidence: REG, PROMACTIVITY, DNABINDING

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: BHLHE40 — TP53 (physical association, affinity chromatography technology) Thin et al., EMBO Rep 2007*
• IRef Dip Interaction: Complex of HDAC1-BHLHE40-TP53 (anti bait coimmunoprecipitation) Qian et al., Proc Natl Acad Sci U S A 2012*
• IRef Dip Interaction: BHLHE40 — TP53 (physical association, anti tag coimmunoprecipitation) Qian et al., Proc Natl Acad Sci U S A 2012*
• IRef Dip Interaction: BHLHE40 — TP53 (physical association, anti bait coimmunoprecipitation) Qian et al., Proc Natl Acad Sci U S A 2012*
• IRef Intact Interaction: BHLHE40 — TP53 (physical association, pull down) Thin et al., EMBO Rep 2007*
• IRef Intact Interaction: BHLHE40 — TP53 (colocalization, imaging technique) Thin et al., EMBO Rep 2007*
• IRef Intact Interaction: BHLHE40 — TP53 (physical association, anti tag coimmunoprecipitation) Thin et al., EMBO Rep 2007*

Text-mined interactions from Literome

Thin et al., EMBO Rep 2007 : In vitro, Stra13 regulates p53 levels in a mouse double mutant 2 (Mdm2) dependent manner by physically interacting with p53 and preventing Mdm2 mediated ubiquitination and nuclear export
Qian et al., Proc Natl Acad Sci U S A 2012 : Surprisingly, we showed that the anti-cell-death activity of DEC1 is p53 dependent , but DEC1 does not directly modulate p53 expression