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HRAS — RALA
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Gotoh et al., J Biol Chem 2000
(Breast Neoplasms) :
In contrast to several other Ral-GEFs, the
Ral GEF activity of AND-34 is not
augmented by constitutively active
Ha-Ras ( Val-12 ), consistent with the absence of a detectable Ras binding domain
Okan et al., Oncogene 2001
:
Here we show that uPAR transcription is stimulated by V12
H-Ras , the effector loop mutant V12 H-Ras G37 and constitutively-active
RalA 72L. RalA dependent transcription
required the presence of the ATF2-like AP1-site at -70 bp and the c-Jun binding motif at -184 bp in the uPAR promoter
Xu et al., Mol Cell Biol 2003
:
These data suggest a model whereby
H-Ras stimulates the activation of both
RalA and ARF6, which together lead to the elevation of PLD activity