Gene interactions and pathways from curated databases and text-mining

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GSK3B — IRS1

Pathways - manually collected, often from reviews:

  • WikiPathways Insulin Signaling: Complex of IRS1-PIK3CA → GSK3B/AKT2/AKT1/SGK3/SGK1/GSK3A/PDPK1/SGK2 (activation)

Text-mined interactions from Literome

Pearce et al., Metabolism 2004 (Body Weight...) : At 29 weeks of age, GSK-3beta protein levels were 5-fold higher, and glycogen synthase activation ( -27 % ), glycogen levels ( -58 % ) and insulin receptor substrate-1 (IRS-1) protein levels ( -67 % ) were significantly reduced in skeletal muscle
Boissan et al., Am J Pathol 2005 (Carcinoma, Hepatocellular...) : IRS-2 overexpression associated with IGF-2 and IRS-1 overexpression and with GSK-3beta inhibition
MacAulay et al., Cell Metab 2007 : Insulin stimulated protein kinase B ( PKB/Akt ) and GSK-3beta phosphorylation was higher in GSK-3alpha KO livers compared to wild-type littermates, and IRS-1 expression was markedly increased
Shimwell et al., Oncogene 2009 (Cell Transformation, Viral) : However, Ad5E1A associates with IRS-1 , increasing Akt and GSK-3beta phosphorylation and tyrosine phosphorylation of IRS-1 itself
Nemoto et al., J Pharmacol Sci 2009 : In cultured bovine adrenal chromaffin cells, 1 ) constitutive and negatively regulated activities of GSK-3beta up- and down-regulated insulin receptor, insulin receptor substrate-1 (IRS-1), IRS-2, and Akt levels via controlling proteasomal degradation and protein synthesis ; 2 ) nicotinic receptor/protein kinase C-alpha (PKC-alpha)/extracellular signal regulated kinase ( ERK ) pathway up-regulated IRS-1 and IRS-2 levels, enhancing insulin induced the phosphoinositide 3-kinase (PI3K)/Akt/GSK-3beta pathway ; 3 ) inhibition of calcineurin by cyclosporin A or FK506 down-regulated IRS-2 level, attenuating insulin-like growth factor-I (IGF-I) induced ERK and GSK-3beta pathways ; and 4 ) insulin, IGF-I or therapeutics ( e.g., lithium ) up-regulated the voltage dependent Na(v)1.7 sodium channel
Leng et al., J Endocrinol 2010 (Insulin Resistance) : Furthermore, overexpression of constitutively active GSK3 beta was sufficient to induce IRS1 degradation