◀ Back to IL6

IL6 — MKL1

Text-mined interactions from Literome

Andreakos et al., Blood 2004 : We found that MyD88 and Mal/TIRAP are essential for LPS induced I kappa B alpha phosphorylation, NF-kappa B activation, and interleukin 6 (IL-6) or IL-8 production in fibroblasts and endothelial cells in a pathway that also requires IKK2 ... In contrast, in macrophages neither MyD88, Mal/TIRAP , nor I kappa B kinase 2 (IKK2) are required for NF-kappa B activation or tumor necrosis factor alpha (TNF alpha), IL-6 , or IL-8 production, although Mal/TIRAP is still involved in the production of interferon beta (IFN beta)
Kenny et al., J Immunol 2009 : Similarly, induction of IL-6 by Salmonella typhimurium, which is sensed by TLR2, required Mal only at low levels of bacteria ... Mal was required for IL-6 induction at all concentrations of the TLR4 ligand LPS