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EGFR — ITGA8
Text-mined interactions from Literome
Yoon et al., Cancer Res 2006
(Breast Neoplasms...) :
In summary, we propose a novel mechanism for ErbB2 up-regulation and Ras activation in serum depleted breast cancer cells
; integrin alpha(6)beta ( 4 )
regulates the expression of ErbB2 and the subsequent phosphorylation of
EGFR and activation of Ras
Chen et al., Mol Cell Biol 2010
:
Thus,
integrin alpha1beta1 negatively
regulates EGFR activation by positively controlling Cav-1 levels, and the ERK/PPARgamma axis plays a key role in regulating integrin alpha1beta1 dependent Cav-1 expression and consequent EGFR mediated ROS production