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HIF1A — STAT3
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Jung et al., FASEB J 2005
(Ischemia...) :
Interestingly, activated
STAT3 increased
HIF-1alpha protein levels due to the HIF-1alpha stability by blocking HIF-1alpha degradation and accelerated its de novo synthesis
Jeong et al., J Biol Chem 2007
:
Our findings collectively suggest that hypoxia induced in vitro differentiation of mESCs is triggered, at least in part, by the
HIF-1alpha mediated suppression of
LIF-STAT3 signaling
Niu et al., Mol Cancer Res 2008
:
Additionally,
Stat3 activity in the nontransformed cells in the tumor milieu
affects HIF-1alpha RNA expression of the entire growing tumor ... Consistent with a
role of
Stat3 in regulating
HIF-1alpha RNA transcription, elevated Stat3 activity increases HIF-1alpha promoter activity, and Stat3 protein binds to the HIF-1alpha promoter in both transformed cells and in growing tumors
Noman et al., J Immunol 2009
(Anoxia...) :
Interestingly, gene silencing of
STAT3 by small interfering RNA
resulted in
HIF-1alpha inhibition and a significant restoration of target cell susceptibility to CTL induced killing under hypoxic conditions by a mechanism involving at least in part down-regulation of AKT phosphorylation
Wincewicz et al., Folia Histochem Cytobiol 2009
(Breast Neoplasms...) :
STAT3 and hypoxia
induced proteins --
HIF-1alpha , EPO and EPOR in relation with Bax and Bcl-xL in nodal metastases of ductal breast cancers
Cascio et al., J Cell Physiol 2010
(Breast Neoplasms) :
In addition, using siRNA knockdown, we demonstrated that the presence of
STAT3 is
necessary for CoCl ( 2 ) -mediated
HIF-1 alpha nuclear accumulation and recruitment on VEGF promoter