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CGN — RHOA
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
CGN
→
RHOA
(direct_complex)
Text-mined interactions from Literome
Aijaz et al., Dev Cell 2005
:
Cingulin binding
inhibits RhoA activation and signaling, suggesting that the increase in cingulin expression in confluent cells causes downregulation of RhoA by inhibiting GEF-H1/Lfc
Paschoud et al., Mol Membr Biol 2008
:
Surprisingly, analysis of these clones by immunoblotting, microarray, immunofluorescence, measurement of transepithelial resistance, and cell density showed that the overexpression of either full-length
cingulin or its domains does not significantly
affect TJ protein levels, gene expression,
RhoA activity, cell density, doubling time, and the organization and function of TJ
Citi et al., Ann N Y Acad Sci 2009
:
The tight junction protein
cingulin regulates gene expression and
RhoA signaling
Guillemot et al., J Cell Sci 2012
(Duodenal Ulcer) :
Cingulin (CGN) is a 140 kDa protein, which is localized to the cytoplasmic region of vertebrate tight junctions ( TJ ), and
regulates gene expression and
RhoA signaling in cultured cells