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SDC2 — TGFB1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Syndecan-2-mediated signaling events: Syndecan-2 (SDC2) → TGFB1 (TGFB1) (modification, collaborate) Klass et al., J Cell Sci 2000*, Chen et al., J Biol Chem 2004*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Syndecan-2-mediated signaling events: Syndecan-2 (SDC2) → Syndecan-2/TGFB1 complex (SDC2-TGFB1) (modification, collaborate)
  Klass et al., J Cell Sci 2000*, Chen et al., J Biol Chem 2004*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Syndecan-2-mediated signaling events: TGFB1 (TGFB1) → Syndecan-2/TGFB1 complex (SDC2-TGFB1) (modification, collaborate)
  Klass et al., J Cell Sci 2000*, Chen et al., J Biol Chem 2004*
  Evidence: mutant phenotype, assay, physical interaction
• Reactome Reaction: SDC2 → TGFB1 (reaction) Ishiguro et al., Glycoconj J 2002*, Chen et al., J Biol Chem 2004*
• Reactome Reaction: SDC2 → TGFB1 (direct_complex) Ishiguro et al., Glycoconj J 2002*, Chen et al., J Biol Chem 2004*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: TGFB1 — SDC2 (in vitro) Chen et al., J Biol Chem 2004*

Text-mined interactions from Literome

Sebestyén et al., Cytokine 2000 : In the present work the regulatory effect of IL-1beta, IL-6, TNF-alpha, IFN-gamma and TGF-beta1 on syndecan-1 and syndecan-2 expression of hepatocytes, hepatoma cell lines, liver and skin fibroblasts has been studied
Worapamorn et al., J Periodontal Res 2002 : In contrast, syndecan-2 mRNA level was markedly upregulated in response to either TGF-beta 1 or IL-1 beta in OB when compared with the other two cell lines ... In contrast, syndecan-2 mRNA level was markedly upregulated in response to either TGF-beta 1 or IL-1 beta in OB when compared with the other two cell lines ... However, the stimulatory effect of TGF-beta 1 on syndecan-2 mRNA production in OB was abolished in the prolonged presence of IL-1 beta
Chen et al., J Biol Chem 2004 (Diabetes Mellitus, Type 2) : Syndecan-2 regulates transforming growth factor-beta signaling
Thesleff et al., Proceedings of the Finnish Dental Society. Suomen Hammaslääkäriseuran toimituksia 1992 : For instance, TGF beta 1 may regulate matrix deposition by increasing tenascin and syndecan expression in the condensed dental mesenchyme and by controlling dentin matrix deposition by odontoblasts
Kolm et al., Am J Physiol 1996 : Furthermore, TGF-beta 1 caused a dose dependent increase in HSPG mRNA levels ... The results indicate that 1 ) TGF-beta 1 protein production is necessary to obtain the high glucose induced effects and 2 ) TGF-beta 1 stimulates mesangial HSPG expression and production
Lambrecht et al., Exp Cell Res 1998 (Breast Neoplasms) : Modification of HSPG induced by TGFbeta-1 or NaB treatments in normal and breast cancer epithelial cells resulted in an increase in 125I-fibroblast growth factor-2 (FGF-2) binding on HSPG