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PLAUR — TGFB1

Text-mined interactions from Literome

Ramont et al., Exp Cell Res 2003 (Disease Models, Animal...) : In contrast, TGF-beta1 triggered a large decrease of uPA and tPA, as well as a decrease of uPA and uPAR mRNAs
Kobayashi et al., Cancer Res 2005 (Chondrosarcoma...) : Here, we show that : ( a ) thalidomide suppresses the expression of constitutive and transforming growth factor-beta1 ( TGF-beta1 ) -induced uPAR mRNA and protein ; ( b ) a nuclear factor kappaB (NF-kappaB) activation system ( phosphorylation of IkappaB-alpha and degradation of IkappaB-alpha ) is necessary for the TGF-beta1 induced increase in uPAR expression, because L-1-tosylamido-2-phenylethyl chloromethyl ketone, a NF-kappaB inhibitor, reduced the uPAR production as well as mRNA expression ; ( c ) thalidomide failed to further strengthen L-1-tosylamido-2-phenylethyl chloromethyl ketone 's action ; ( d ) the once-daily i.p. administration of thalidomide ( 400 microg/g body weight/d ) decreased progressive growth of HRA tumors and ascites formation in an in vivo animal model ; and ( e ) the once-daily i.p. administration of thalidomide in combination with paclitaxel ( i.p., 100 microg/20 g at days 2 and 5 ) significantly decreased progressive growth of HRA cells in a synergistic fashion
Lund et al., Biochem J 1995 : We have previously found that transforming growth factor-beta , type 1 ( TGF-beta 1 ), increases uPAR gene transcription in the human lung carcinoma cell line A549 and now report that also epidermal growth factor (EGF) and the tumour promoter phorbol 12-myristate 13-acetate ( PMA ) cause increased uPAR transcription and that PMA and TGF-beta 1 in addition increase the stability of uPAR mRNA, while EGF has no effect on this parameter
Nykjaer et al., J Immunol 1994 : In addition, TGF-beta 1 substantially reduced the uPAR expression in T cell cultures responding to PHA, IL-2, and IL-7
Simon et al., Blood 1996 (Leukemia, Monocytic, Acute...) : Induction of Mac-1 and uPAR expression on monocytic cell lines by transforming growth factor- beta 1 and 1.25- ( OH ) 2 vitamin D3 conferred urokinase and uPAR dependent adhesion to vitronectin, which was further promoted by engagement of Mac-1
Albo et al., Surgery 1997 (Breast Neoplasms...) : uPAR expression was up-regulated more than twofold by both TSP-1 and TGF-beta 1
Albo et al., J Surg Res 1998 (Adenocarcinoma...) : In this study, we determined the effect of TSP-1 and TGF-beta 1 on uPA and uPAR expression and on tumor cell invasion in pancreatic cancer