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ANK1 — TGFB1

Text-mined interactions from Literome

Hirose et al., Arthritis Rheum 2002 (Chondrocalcinosis...) : Both CILP and ANK mRNA expression and ePPi elaboration were stimulated by TGFbeta1 and inhibited by IGF-1 in chondrocytes from all sources
Cailotto et al., Arthritis Res Ther 2007 (Chondrocalcinosis...) : As transforming growth factor-beta-1 ( TGF-beta1 ) was shown to favor calcium pyrophosphate dihydrate deposition, we investigated the contribution of ANK to the production of extracellular inorganic pyrophosphate ( ePPi ) by chondrocytes and the signaling pathways involved in the regulation of Ank expression by TGF-beta1 ... Finally, selective kinase inhibitors and dominant-negative/overexpression plasmid strategies were used to explore the contribution of several signaling pathways to Ank induction by TGF-beta1 ... TGF-beta1 strongly increased Ank expression at the mRNA and protein levels, as well as ePPi production ... These data suggest a regulatory role for calcium in TGF-beta1 induced Ank expression