◀ Back to IGF1
IGF1 — RB1
Text-mined interactions from Literome
Hirschfeld et al., In Vivo 1994
(Bone Neoplasms...) :
Insulin-like growth factor-I may
regulate osteosarcoma and the Ewing 's family of tumors ( primitive neuroectodermal tumors )
Dufourny et al., J Biol Chem 1997
(Breast Neoplasms) :
In contrast, all of the observed stimulatory
effects of
IGF-I on cell cycle progression, cyclin D1 synthesis, and
pRb hyperphosphorylation were blocked by the specific phosphatidylinositol 3-kinase inhibitor LY294002, suggesting that phosphatidylinositol 3-kinase activity but not MAPK activity is required for transduction of the mitogenic IGF-I signal in MCF-7 cells